Human Glucocorticoid Receptor (GR, NR3C1) Stable Cells

Human Glucocorticoid Receptor (GR, NR3C1) Stable Cells
Model: CLHKGR01
Species: Human
Catalog Number: CLHKGR01
Availability: In Stock
Price: $799.00
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Introduction:

Nuclear hormone receptors (NHRs) are a superfamily of transcription factors that function as powerful metabolic regulators to control a variety of systemic processes in physiology. They also play key roles in the pathophysiology of many major disease states, such as diabetes, obesity, inflammation, atherosclerosis and heart failure. To date, this superfamily has provided a rich source of drug design targets and it is continuing to be one of the hottest areas for pharmaceutical research.

PrimCells now provides a comprehensive set of NHR expressing cell lines to the research community. These high-quality, Flag and/or HA-tagged NHR-expressing cell lines aim to facilitate further biochemical and molecular studies of their functions and hence encourage new strategies for drug design.

Glucocorticoids (GCs) are steroid hormones that allow us to cope with environmental and physiological stresses. Although GCs are widely used as anti-inflammatory agents in several clinical areas, long-term use of those steroids causes problems instead. Full achievement of the clinical potential of GCs necessitates limiting the side effects of these drugs.

The lipophilic nature of GCs allows them to readily diffuse into the cells, where they bind to a cytosolic receptor, the Glucocorticoid Recetpor (GR) to exert their mechanism of action. Without ligand binding, GR is predominantly localized in cytoplasm, whereas upon ligand binding it rapidly translocates to nucleus where it can both positively and negatively regulate gene expression. GR belongs to the nuclear receptor superfamily of ligand-activated transcription factors that function as powerful metabolic regulators.

The GR stable cell line (Flag and HA tagged)/HEK293 cell line was created by stable transfection of HEK293 cells with a plasmid expressing Flag and HA tagged GR protein.

Click here to download PDF datasheet
Click here to download PDF datasheet

For additional information regarding the product and technical questions, please contact Supports@PrimCells.com.  You are guaranteed to receive a response within 24hrs from one of our scientists.Supports@PrimCells.com

This product is intended for laboratory research purposes only. It is not intended for use in humans. While PrimCells uses reasonable efforts to include accurate and up-to-date information on this product sheet, PrimCells makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. PrimCells does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. PrimCells is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, PrimCells is not liable for damages arising from the misidentification or misrepresentation of cultures.

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